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COMPOUND
GV1001 is a synthetic peptide of 16 amino acids based on the key sequence of telomerase function.
GV1001 modulates phenotypes of glial cells, regulating neuroinflammation in Neurodegenerative Diseases.
  • 1
    Microglia-mediated neuroinflammation

    Inhibition of microglial activation induced by tau aggregation and Aβ deposition. Reduction of Aβ plaques burden and tau aggregation via microglial phagocytosis. Reduced production of pro-inflammatory cytokines caused by neuroinflammation.

  • 2
    Reactive astrocytes

    Inhibition of astrocyte reactivation induced by p-tau and Aβ plaques.

  • 3
    Neurodegeneration

    Reduced neuronal synaptic degeneration. Improves memory deficits and locomotor deficits.

GemVax focuses on therapeutic strategies targeting glial cell-mediated neuroinflammation to treat neurodegenerative diseases.
  • 1
    Alzheimer’s disease (AD) Hallmarks

    Amyloid β plaques Neurofibrillary tangles composed of hyperphosphorylated tau protein

  • 2
    Progressive supranuclear palsy (PSP) Rare neurodegeneration disease Hallmarks

    Deposition of fibrillar aggregates of 4-repeat (4R) tau protein

  • 3
    Parkinson’s disease (PD) Hallmarks

    Accumulation of α-synuclein in Lewy bodies

  • 4
    Amyotrophic Lateral Sclerosis (ALS) Rare neurodegeneration disease Hallmarks

    Genetic alterations of C9orf72, SOD1, TARDBP genes

  • 5
    Multiple sclerosis (MS) Rare neurodegenerative disease, Chronic inflammatory demyelinating disease Hallmarks

    Demyelination (damage to the myelin sheath around neurons in the CNS)